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단백질 유전체 정보
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데이터 상품 정보 |
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1. 상품 설명 및 특징
- 약재의 구성성분과 단백질, 단백질과 단백질 상호작용에 존재하는 단백질 목록입니다.
2. 컬럼(속성) 정보
- 단백질아이디(PROT_ID): 단백질 아이디
- 단백질심볼(PROT_SMBL_NM): 단백질 심볼 이름
- 단백질서열길이(PROT_ORDE_LNGTH): 단백질 서열 길이
- 단백질이름(LVBNG_PROT_NM): 단백질 이름
- 단백질TAXONOMY코드(PROT_TXNM_CD): 단백질 NCBI Taxonomy 코드
- 날짜(LDNG_DT): 데이터 적재일 (샘플에는 날짜 컬럼이 없습니다.)
3. 활용 예시
- 본 상품에 있는 단백질들간의 상호작용은 성분-타겟 매핑 정보 상품에서 확인할 수 있습니다.
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데이터 키워드 |
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| 약용 생물자원, 약재, 단백질, 유전체, 목록 |
| 판매제공처 | 데이터 등록일 | 데이터 수정일 | 데이터 이용기한 |
|---|---|---|---|
| 한국한의학연구원 | 2019-12-27 | 2021-11-26 | 무기한 |
| 상품 구분 | 데이터 배포 주기 | 데이터 제공 포맷/압축 포맷 | 데이터 제공 방식 | 데이터 파일 용량 |
|---|---|---|---|---|
| dataset | 1년 | csv/zip | 다운로드 | 434.29 MB |
| 단백질ID | 단백질심볼명 | 단백질서열길이 | 생물단백질명 | 단백질분류학코드 | |||||||||||||||
| 9606.ENSP00000003084 | CFTR | 1480 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] | 9606 | |||||||||||||||
| 9606.ENSP00000012443 | PPP5C | 499 | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E | ASK1/MAP3K5 | PRKDC and RAF1 | the nuclear receptors NR3C1 | PPARG | ESR1 and ESR2 | SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes | including apoptosis | differentiation | DNA damage response | cell survival | regulation of ion channels or circadian rhythms | in response to steroid and thyroid hormones | calcium | fatty acids | TGF-beta as well as oxidative and genotoxic stresses. Pa [...] | 9606 |
| 9606.ENSP00000200676 | CETP | 493 | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids | including cholesteryl ester and triglyceride | among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL | and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport | by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 9606 | |||||||||||
| 9606.ENSP00000209668 | ADH1A | 375 | Alcohol dehydrogenase 1A | alpha polypeptide; Belongs to the zinc-containing alcohol dehydrogenase family | 9606 | ||||||||||||||
| 9606.ENSP00000212015 | SIRT1 | 747 | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle | response to DNA damage | metobolism | apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA | leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators | thereby regulating target gene expres [...] | 9606 | ||||||||||
| 9606.ENSP00000216392 | PYGL | 847 | Glycogen phosphorylase | liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However | all known phosphorylases share catalytic and structural properties | 9606 | |||||||||||||
| 9606.ENSP00000216479 | AHSA1 | 338 | Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1 | thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins | 9606 | ||||||||||||||
| 9606.ENSP00000221930 | TGFB1 | 390 | Transforming growth factor beta-1; Multifunctional protein that controls proliferation | differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation | causing chemotaxis | proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...] | 9606 | ||||||||||||
| 9606.ENSP00000223095 | SERPINE1 | 402 | Plasminogen activator inhibitor 1; Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator | urokinase | protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis; Serpin peptidase inhibitors | 9606 | |||||||||||||
| 9606.ENSP00000225577 | RPS6KB1 | 525 | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation | cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B | RPS6 and EEF2K | and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion | the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation | phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] | 9606 | ||||||||||
| 9606.ENSP00000225740 | ALDH3A1 | 453 | ALIAS(9606.ENSP00000411821)Aldehyde dehydrogenase | dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids | biogenic amines | neurotransmitters | and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity) | 9606 | |||||||||||
| 9606.ENSP00000227758 | BIRC2 | 618 | ALIAS(9606.ENSP00000477613)Baculoviral IAP repeat-containing protein 2; Multi-functional protein which regulates not only caspases and apoptosis | but also modulates inflammatory signaling and immunity | mitogenic kinase signaling | and cell proliferation | as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target protein [...] | 9606 | |||||||||||
| 9606.ENSP00000229794 | MAPK14 | 360 | ALIAS(9606.ENSP00000229795)Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly | p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 9606 | ||||||||||||||
| 9606.ENSP00000229795 | MAPK14 | 360 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly | p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 9606 | ||||||||||||||
| 9606.ENSP00000231887 | EHHADH | 723 | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family | 9606 | |||||||||||||||
| 9606.ENSP00000233242 | APOB | 4563 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48) | LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor; Apolipoproteins | 9606 | ||||||||||||||
| 9606.ENSP00000236850 | APOA1 | 267 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex | activates spermatozoa motility; Apolipoproteins | 9606 | ||||||||||||||
| 9606.ENSP00000241052 | CAT | 527 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells | B-cells | myeloid leukemia cells | melanoma cells | mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family | 9606 | |||||||||||
| 9606.ENSP00000250378 | CMA1 | 247 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation | extracellular matrix degradation | and regulation of gland secretion | 9606 | |||||||||||||
| 9606.ENSP00000252519 | ACE2 | 805 | ALIAS(9606.ENSP00000389326)Angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9 | a peptide of unknown function | and angiotensin II to angiotensin 1-7 | a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function | 9606 | ||||||||||||
| 9606.ENSP00000252818 | JUND | 347 | Transcription factor jun-D; Transcription factor binding AP-1 sites; Belongs to the bZIP family. Jun subfamily | 9606 | |||||||||||||||
| 9606.ENSP00000253799 | AOC2 | 756 | Retina-specific copper amine oxidase; Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina | 9606 | |||||||||||||||
| 9606.ENSP00000262158 | SMAD7 | 426 | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1 | which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...] | 9606 | ||||||||||||||
| 9606.ENSP00000262160 | SMAD2 | 467 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and | on formation of the SMAD2/SMAD4 complex | activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | 9606 | |||||||||||||
| 9606.ENSP00000262367 | CREBBP | 2442 | CREB-binding protein; Acetylates histones | giving a specific tag for transcriptional activation. Also acetylates non-histone proteins | like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excisi [...] | 9606 | |||||||||||||
| 9606.ENSP00000262735 | PPARA | 468 | ALIAS(9606.ENSP00000385523)Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide | a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 9606 | ||||||||||||||
| 9606.ENSP00000263253 | EP300 | 2414 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac) | a modification that localizes at the surface of the histone octamer and stimulates transcription | possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K [...] | 9606 | |||||||||||||
| 9606.ENSP00000263464 | BIRC3 | 604 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis | but also modulates inflammatory signaling and immunity | mitogenic kinase signaling and cell proliferation | as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] | 9606 | ||||||||||||
| 9606.ENSP00000263923 | KDR | 1356 | Vascular endothelial growth factor receptor 2; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA | VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis | vascular development | vascular permeability | and embryonic hematopoiesis. Promotes proliferation | survival | migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain | such as isoform 2 and isoform 3 | may function as decoy receptors for VEGFA | VEGFC and/or VEGFD. Isoform 2 plays an important role as negative reg [...] | 9606 | ||||||
| 9606.ENSP00000264005 | LCAT | 440 | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes | and esterifies free cholesterol on nascent APOE- [...] | 9606 | ||||||||||||||
| 9606.ENSP00000264110 | ATF2 | 505 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes | including those involved in anti- apoptosis | cell growth | and DNA damage response. Dependent on its binding partner | binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus | contributes to global transcription and the DNA damage response | in addition to specific transcriptional activities that are related to cell development | proliferation and death. In the cy [...] | 9606 | ||||||||
| 9606.ENSP00000264657 | STAT3 | 770 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins | KITLG/SCF | LEP and other growth factors. Once activated | recruits coactivators | such as NCOA1 or MED1 | to the promoter region of the target gene. May mediate cellular responses to activated FGFR1 | FGFR2 | FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differenti [...] | 9606 | ||||||||
| 9606.ENSP00000264867 | PPARGC1A | 798 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 9606 | |||||||||||||||
| 9606.ENSP00000265023 | KNG1 | 644 | Kininogen-1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction | (4B) induction of hypotension | (4C) natriuresis and diuresis | (4D) decrease in blood glucose level | (4E) it is a mediator of inflammation [...] | 9606 | |||||||||||
| 9606.ENSP00000265512 | ADH4 | 380 | Alcohol dehydrogenase 4 | pi polypeptide | 9606 | ||||||||||||||
| 9606.ENSP00000265641 | CPT1A | 773 | Carnitine O-palmitoyltransferase 1 | liver isoform; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine | an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism | 9606 | |||||||||||||
| 9606.ENSP00000265838 | ACAT1 | 427 | Acetyl-CoA acetyltransferase | mitochondrial; Plays a major role in ketone body metabolism | 9606 | ||||||||||||||
| 9606.ENSP00000265960 | MAPKAP1 | 522 | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2 | which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors | but | in contrast to mTORC1 | seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton | probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation | which may facilitate the phosphorylation of the [...] | 9606 | |||||||||
| 9606.ENSP00000269305 | TP53 | 393 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression | or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 9606 | ||||||||||||||
| 9606.ENSP00000270202 | AKT1 | 480 | ALIAS(9606.ENSP00000451828)RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1 | AKT2 and AKT3) called the AKT kinase | and which regulate many processes including metabolism | proliferation | cell survival | growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far | but for most of them | no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of th [...] | 9606 | ||||||||
| 9606.ENSP00000272190 | REN | 406 | Renin; Renin is a highly specific endopeptidase | whose only known function is to generate angiotensin I from angiotensinogen in the plasma | initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | 9606 | |||||||||||||
| 9606.ENSP00000273430 | AGTR1 | 359 | ALIAS(9606.ENSP00000419422)Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 9606 | |||||||||||||||
| 9606.ENSP00000281455 | ACSL1 | 698 | ALIAS(9606.ENSP00000422607)Long-chain-fatty-acid--CoA ligase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids | and degradation via beta-oxidation. Preferentially uses palmitoleate | oleate and linoleate; Acyl-CoA synthetase family | 9606 | |||||||||||||
| 9606.ENSP00000282397 | FLT1 | 1338 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA | VEGFB and PGF | and plays an essential role in the development of embryonic vasculature | the regulation of angiogenesis | cell survival | cell migration | macrophage function | chemotaxis | and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation | survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...] | 9606 | ||||||
| 9606.ENSP00000285093 | ACAA2 | 397 | 3-ketoacyl-CoA thiolase | mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 9606 | ||||||||||||||
| 9606.ENSP00000287820 | PPARG | 505 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand | the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes | such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 9606 | |||||||||||||
| 9606.ENSP00000287936 | HMGCR | 888 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family | 9606 | |||||||||||||||
| 9606.ENSP00000290866 | ACE | 1306 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu | this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin | a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety; CD molecules | 9606 | |||||||||||||
| 9606.ENSP00000293217 | ACOX1 | 660 | Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1 | 16-hexadecanodioyl- CoA | 9606 | ||||||||||||||
| 9606.ENSP00000294724 | AGL | 1532 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1 | 4-alpha-D-glucan:1 | 4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1 | 6- glucosidase in glycogen degradation; Belongs to the glycogen debranching enzyme family | 9606 | ||||||||||||
| 9606.ENSP00000296412 | ADH5 | 374 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol | but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily | 9606 | ||||||||||||||
| 9606.ENSP00000301645 | CYP7A1 | 504 | Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis; Cytochrome P450 family 7 | 9606 | |||||||||||||||
| 9606.ENSP00000306245 | FOS | 380 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer | FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation | forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction | cell proliferation and different [...] | 9606 | ||||||||||||
| 9606.ENSP00000306662 | ADRA1B | 520 | Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily | 9606 | |||||||||||||||
| 9606.ENSP00000312189 | CPT1B | 772 | ALIAS(9606.ENSP00000379011)Carnitine O-palmitoyltransferase 1 | muscle isoform; Carnitine palmitoyltransferase 1B | 9606 | ||||||||||||||
| 9606.ENSP00000312189 | CHKB | 395 | ALIAS(9606.ENSP00000384400)Choline/ethanolamine kinase; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine | and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis; Belongs to the choline/ethanolamine kinase family | 9606 | ||||||||||||||
| 9606.ENSP00000312326 | AOC3 | 763 | Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis | 9606 | |||||||||||||||
| 9606.ENSP00000325136 | HADHB | 474 | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | 9606 | |||||||||||||||
| 9606.ENSP00000326305 | SLC25A20 | 301 | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway; Solute carriers | 9606 | |||||||||||||||
| 9606.ENSP00000332256 | ALDH1A3 | 512 | Aldehyde dehydrogenase family 1 member A3; NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal | and has much lower in vitro activity with acetaldehyde. Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity) | 9606 | ||||||||||||||
| 9606.ENSP00000332973 | SMAD3 | 425 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and | on formation of the SMAD3/SMAD4 complex | activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and mi [...] | 9606 | |||||||||||||
| 9606.ENSP00000333664 | ACAA1 | 424 | 3-ketoacyl-CoA thiolase | peroxisomal; acetyl-CoA acyltransferase 1 | 9606 | ||||||||||||||
| 9606.ENSP00000335153 | HSP90AA1 | 854 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation | structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins | thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition | ATPase cycle and chaperone function. Engages with a ra [...] | 9606 | ||||||||||||
| 9606.ENSP00000338018 | HIF1A | 850 | ALIAS(9606.ENSP00000437955)Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions | activates the transcription of over 40 genes | including erythropoietin | glucose transporters | glycolytic enzymes | vascular endothelial growth factor | HILPDA | and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization | tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia res [...] | 9606 | |||||||
| 9606.ENSP00000340684 | MAOA | 527 | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT) | norepinephrine and epinephrine; Belongs to the flavin monoamine oxidase family | 9606 | ||||||||||||||
| 9606.ENSP00000341390 | NR3C2 | 984 | ALIAS(9606.ENSP00000350815)Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels; Nuclear hormone receptors | 9606 | |||||||||||||||
| 9606.ENSP00000341551 | SMAD4 | 552 | Mothers against decapentaplegic homolog 4; In muscle physiology | plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN | promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By s [...] | 9606 | |||||||||||||
| 9606.ENSP00000344818 | UBC | 685 | ALIAS(9606.ENSP00000441543)Polyubiquitin-C; Ubiquitin: Exists either covalently attached to another protein | or free (unanchored). When covalently bound | it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin) | a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains | when attached to a target protein | have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; [...] | 9606 | ||||||||||
| 9606.ENSP00000350815 | NR3C2 | 984 | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels; Nuclear hormone receptors | 9606 | |||||||||||||||
| 9606.ENSP00000353483 | MAPK8 | 427 | ALIAS(9606.ENSP00000378974)Mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation | differentiation | migration | transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade | two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn | MAPK8/JNK1 phosphorylates a number of transcription factors | primarily components of AP-1 such as JU [...] | 9606 | |||||||||
| 9606.ENSP00000354476 | SREBF2 | 1141 | Sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes; Basic helix-loop-helix proteins | 9606 | |||||||||||||||
| 9606.ENSP00000354995 | ABCG1 | 678 | ATP-binding cassette sub-family G member 1; Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages; ATP binding cassette subfamily G | 9606 | |||||||||||||||
| 9606.ENSP00000355627 | AGT | 485 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS) | a potent regulator of blood pressure | body fluid and electrolyte homeostasis; Endogenous ligands | 9606 | |||||||||||||
| 9606.ENSP00000356015 | ACAT2 | 397 | Acetyl-CoA acetyltransferase | cytosolic; acetyl-CoA acetyltransferase 2 | 9606 | ||||||||||||||
| 9606.ENSP00000360918 | CH25H | 272 | Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol | leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha | 25-dihydroxycholesterol (7-alpha | 25-OHC) | an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2 | a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element [...] | 9606 | ||||||||||
| 9606.ENSP00000360973 | AGTR2 | 363 | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation | 9606 | |||||||||||||||
| 9606.ENSP00000362401 | CYSLTR1 | 337 | ALIAS(9606.ENSP00000478492)Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle | edema | eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4 | 9606 | |||||||||||||
| 9606.ENSP00000363512 | ALOX5 | 674 | Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis | and thereby plays a role in inflammatory processes; Belongs to the lipoxygenase family | 9606 | ||||||||||||||
| 9606.ENSP00000363868 | ABCA1 | 2261 | ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family | 9606 | |||||||||||||||
| 9606.ENSP00000366534 | FOXH1 | 365 | Forkhead box protein H1; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element); Forkhead boxes | 9606 | |||||||||||||||
| 9606.ENSP00000367309 | MAOB | 520 | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 9606 | |||||||||||||||
| 9606.ENSP00000367959 | HTR2A | 471 | ALIAS(9606.ENSP00000437737)5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances | including mescaline | psilocybin | 1-(2 | 5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 9606 | |||||||||||
| 9606.ENSP00000368766 | ADRA1D | 572 | Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Adrenoceptors | 9606 | |||||||||||||||
| 9606.ENSP00000369960 | ADRA1A | 475 | Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily | 9606 | |||||||||||||||
| 9606.ENSP00000378359 | ADH6 | 375 | Alcohol dehydrogenase 6 | 9606 | |||||||||||||||
| 9606.ENSP00000378974 | MAPK8 | 427 | Mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation | differentiation | migration | transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade | two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn | MAPK8/JNK1 phosphorylates a number of transcription factors | primarily components of AP-1 such as JU [...] | 9606 | |||||||||
| 9606.ENSP00000379011 | CPT1B | 772 | Carnitine O-palmitoyltransferase 1 | muscle isoform; Carnitine palmitoyltransferase 1B | 9606 | ||||||||||||||
| 9606.ENSP00000385523 | PPARA | 468 | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide | a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 9606 | ||||||||||||||
| 9606.ENSP00000387699 | CREB1 | 341 | Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE) | a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells; Basic leucine zipper proteins | 9606 | ||||||||||||||
| 9606.ENSP00000389326 | ACE2 | 805 | Angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9 | a peptide of unknown function | and angiotensin II to angiotensin 1-7 | a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function | 9606 | ||||||||||||
| 9606.ENSP00000410833 | GBE1 | 702 | 1 | 4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily | 9606 | ||||||||||||||
| 9606.ENSP00000411821 | ALDH3A1 | 453 | Aldehyde dehydrogenase | dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids | biogenic amines | neurotransmitters | and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity) | 9606 | |||||||||||
| 9606.ENSP00000419422 | AGTR1 | 359 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 9606 | |||||||||||||||
| 9606.ENSP00000422607 | ACSL1 | 698 | Long-chain-fatty-acid--CoA ligase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids | and degradation via beta-oxidation. Preferentially uses palmitoleate | oleate and linoleate; Acyl-CoA synthetase family | 9606 | |||||||||||||
| 9606.ENSP00000437737 | HTR2A | 471 | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances | including mescaline | psilocybin | 1-(2 | 5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] | 9606 | |||||||||||
| 9606.ENSP00000437955 | HIF1A | 850 | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions | activates the transcription of over 40 genes | including erythropoietin | glucose transporters | glycolytic enzymes | vascular endothelial growth factor | HILPDA | and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization | tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia res [...] | 9606 | |||||||
| 9606.ENSP00000441543 | UBC | 685 | Polyubiquitin-C; Ubiquitin: Exists either covalently attached to another protein | or free (unanchored). When covalently bound | it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin) | a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains | when attached to a target protein | have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; [...] | 9606 | ||||||||||
| 9606.ENSP00000442656 | ACVR1B | 546 | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival | hair follicle development and cycling | FSH production by the pituitary gland | wound healing | extracellular matrix production | immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine [...] | 9606 | ||||||||||
| 9606.ENSP00000451828 | AKT1 | 480 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1 | AKT2 and AKT3) called the AKT kinase | and which regulate many processes including metabolism | proliferation | cell survival | growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far | but for most of them | no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of th [...] | 9606 | ||||||||
| 9606.ENSP00000473990 | ALDH3B1 | 468 | Aldehyde dehydrogenase family 3 member B1; Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3 | 4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation | 9606 |
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